Key result
AF with functional MR associates with ~66% lower mitral annulus area fraction and altered geometry.
Why the study?
Meticulous understanding of the mechanisms underpinning mitral regurgitation in AF patients is crucial to optimize therapeutic strategies.
Does high volume rate 3D-TEE identify differences in mitral valve geometry in nonvalvular atrial fibrillation patients with and without left ventricular dysfunction?
Observational (n=104)
Single-blind
No
Does high volume rate 3D-TEE identify differences in mitral valve geometry in nonvalvular atrial fibrillation patients with and without left ventricular dysfunction?
Absolute Event Rate: 7.2% vs 21.3%
p-value: p=0.001
High volume rate 3D-TEE demonstrates that atrial functional mitral regurgitation in AF patients is driven by mitral annulus dilatation, flattening, and atriogenic posterior mitral leaflet tethering, which is further aggravated by LV dysfunction.
3D-TEE identifies mitral geometric changes in AFMR; hypothesis-generating and should not change practice pending prospective validation.
Meticulous understanding of the mechanisms underpinning mitral regurgitation in atrial fibrillation (AF) patients is crucial to optimize therapeutic strategies. The morphologic characteristics of mitral valves in atrial functional mitral regurgitation (FMR) patients with and without left ventricular (LV) dysfunction were evaluated by high volume rate (HVR) three-dimensional transesophageal echocardiography (3D-TEE). In our study, 68 of 265 AF patients who underwent 3D-TEE were selected, including 36 patients with AF, FMR, and preserved LV function (AFMR group) and 32 patients with AF, FMR, and LV dysfunction (VFMR group). In addition, 36 fever patients without heart disease were included in the control group. Group comparisons were performed by one-way analysis of variance for continuous variables. The left atrium (LA) was enlarged in the AFMR and VFMR groups compared with the control group. The mitral annulus (MA) in the AFMR group was enlarged and flattened compared with the control group and was smaller than in the VFMR group. The annulus area fraction was significantly diminished in the AFMR and VFMR groups, indicative of reduced MA contractility. The posterior mitral leaflet (PML) angle was smallest in the AFMR group and largest in the control group, whereas the distal anterior mitral leaflet angle did not significantly differ among the three groups. LA remodeling causes expansion of the MA and reduced MA contractility, disruption of the annular saddle shape, and atriogenic PML tethering. Comparison of atrial FMR patients with and without LV dysfunction indicates that atriogenic PML tethering is an important factor that aggravates FMR. HVR 3D-TEE improves the 3D temporal resolution greatly.
No takes yet. Share an insight, caveat, or question.
Bai et al. (2023) conducted an observational in Nonvalvular atrial fibrillation with functional mitral regurgitation (n=104). Atrial fibrillation with functional mitral regurgitation vs. Patients without heart disease (controls) was evaluated on Annulus area fraction (AAF) (p=0.001). Atrial fibrillation with functional mitral regurgitation was associated with significantly reduced mitral annulus area fraction (7.2% vs 21.3% in controls) and altered mitral valve geometry.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: