Key result
Angiotensin II increases platelet intracellular calcium, amplified by ACE inhibition and reduced by nifedipine.
This study demonstrates that angiotensin II increases intracellular calcium in human platelets, an effect modulated by extracellular calcium, ACE inhibition, and nifedipine.
No immediate clinical implications for ACE inhibitor or calcium-channel blocker use; leaves open mechanistic platelet studies in humans.
Our study on intracellular effects of angiotensin II in human platelets showed that: (1) angiotensin II increases intracellular free calcium in platelets via a receptor-operated mechanism and this increase is dose-dependent; (2) the effect on platelet intracellular free calcium depends on the extracellular calcium concentration; (3) ACE inhibition leads to an increased sensitivity of intracellular free calcium to angiotensin II but does not alter epinephrine-induced calcium increase; (4) nifedipine reduces the susceptibility of platelet intracellular free calcium for angiotensin II.
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Haller et al. (1987) studied this question. Angiotensin II was evaluated on Intracellular free calcium in platelets. Angiotensin II increases intracellular free calcium in human platelets in a dose-dependent manner, with sensitivity increased by ACE inhibition and reduced by nifedipine.
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