Key result
Intravenous infusion of angiotensin II in healthy males increased plasma β-thromboglobulin levels by 66 ± 24% and caused mild activation of the coagulation cascade.
Why the study?
Does intravenous infusion of angiotensin II affect platelet function and coagulation in healthy males?
Population
18 healthy males
Design
Other
Follow-up
during the infusion
Authors
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May warrant caution in high-angiotensin states; hypothesis-generating for prothrombotic effects in patients.
Does intravenous infusion of angiotensin II affect platelet function and coagulation in healthy males?
Intravenous angiotensin II infusion causes mild platelet activation and enhances coagulation in healthy males, though the clinical relevance remains to be clarified.
Larsson et al. (2000) studied Healthy volunteers (n=18). Angiotensin II was evaluated on Plasma β-thromboglobulin levels. Intravenous infusion of angiotensin II in healthy males increased plasma β-thromboglobulin levels by 66 ± 24% and caused mild activation of the coagulation cascade.
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