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April 1, 1992Clinical Science

Dose-response study of the redistribution of intravascular volume by angiotensin II in man

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Why the study?

Does angiotensin II infusion alter systemic and regional haemodynamic indices in normal male subjects?

Population

n=8 normal male subjects

Comparison

Angiotensin II infusion at increasing rates vs Placebo [5% (w/v) d-glucose]

Design

Other

Authors

JMJoseph G. MotwaniASAllan D. Struthers

Discussion

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Overview

May inform volume redistribution mechanisms in heart failure; leaves open clinical translation from healthy volunteer data.

Structured PICO

Does angiotensin II infusion alter systemic and regional haemodynamic indices in normal male subjects?

P
Population
n=8 normal male subjects
I
Intervention
Angiotensin II infusion at increasing rates (1, 3, or 10 ng min−1 kg−1)
C
Comparator
Placebo [5% (w/v) d-glucose]
O
Outcome
Response of systemic and regional haemodynamic indices (including total peripheral resistance, cardiac output, renal blood flow, calf blood flow, and calf venous capacitance)surrogate

High-dose angiotensin II infusion causes venodilatation and increases calf blood flow, suggesting a potential mechanism for favorable blood flow redistribution in conditions with inappropriate extracellular fluid volume expansion like chronic heart failure.

Cite This Study

Motwani et al. (1992) studied this question.

synapsesocial.com/papers/6a8d1916c2b23cc7decdb8bbhttps://doi.org/10.1042/cs0820397
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II attenuates reflex decrease in heart rate and sympathetic activity in man1988 · 11 citations
  2. 2Effects of Angiotensin II and Aldosterone on Diastolic Function In Vivo in Normal Man1994 · 14 citations
  3. 3The Response of Blood Pressure to Infusion of Angiotensin II: Relation to Plasma Concentrations of Renin and Angiotensin II1972 · 110 citations
  4. 4Comparative effects of angiotensin II on Doppler parameters of left and right heart systolic and diastolic blood flow.1994 · 13 citations
  5. 5Dissociation between the renal effects of angiotensin I and II in sodium-restricted normal subjects1998 · 8 citations