Key result
Angiotensin II infusion prolongs isovolumic relaxation time by ~12 ms vs placebo.
Why the study?
The effects of angiotensin II and aldosterone on diastolic function in normal humans were not well characterized in vivo.
Do infusions of angiotensin II and aldosterone affect diastolic function and systemic haemodynamics in normal male subjects?
Population
10 normal male subjects
Comparison
Infusions of angiotensin II and D-aldosterone versus placebo
Design
Randomized controlled trial
Authors
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Ang II impairs LV diastolic filling independently of aldosterone even at sub-pressor doses in healthy men; extends evidence for direct RAAS effects on relaxation.
RCT (n=10)
Do infusions of angiotensin II and aldosterone affect diastolic function and systemic haemodynamics in normal male subjects?
Mean Difference: 12 (95% CI 8.2–15.8)
p-value: p=< 0.001
Angiotensin II impairs left ventricular diastolic filling independently of its effect on aldosterone release, even at sub-pressor concentrations.
Clarkson et al. (1994) conducted an RCT in Healthy (n=10). Angiotensin II and D-aldosterone vs. Placebo [0.9% (w/v) NaCl] was evaluated on Isovolumic relaxation time (MD 12.0 ms, 95% CI 8.2-15.8, p=< 0.001). Angiotensin II infusion produced a dose-related prolongation of isovolumic relaxation time (MD 12.0 ms; 95% CI 8.2-15.8; P<0.001 at 10 ng min-1 kg-1) compared with placebo.
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