Key result
Angiotensin II is 10 times as potent as norepinephrine in normal subjects and 2-3 times as potent in patients in shock, increasing blood pressure and peripheral resistance without tachyphylaxis.
Why the study?
Does angiotensin II alter hemodynamic properties compared to norepinephrine in normal subjects and patients in shock?
Population
Normal subjects and patients in shock
Comparison
Angiotensin II (continuous administration) vs Norepinephrine
Design
Other
Authors
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May support angiotensin II as potent vasopressor in shock; leaves open comparative efficacy versus norepinephrine in modern trials.
Observational
Does angiotensin II alter hemodynamic properties compared to norepinephrine in normal subjects and patients in shock?
Angiotensin II is a highly potent pressor agent that significantly increases peripheral resistance and blood pressure without causing tissue sloughing upon extravasation.
Finnerty et al. (1961) conducted an observational in Normal subjects and patients in shock. Angiotensin II vs. Norepinephrine was evaluated on Hemodynamic properties and potency. Angiotensin II is 10 times as potent as norepinephrine in normal subjects and 2-3 times as potent in patients in shock, increasing blood pressure and peripheral resistance without tachyphylaxis.
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