January 1, 2000Blood Coagulation & Fibrinolysis

Platelet activation during angiotensin II infusion in healthy volunteers

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Why the study?

Does intravenous infusion of angiotensin II activate platelets and coagulation in healthy males?

Population

18 healthy males

Design

Other

Follow-up

during the infusion

Authors

PLP. T. LarssonKarolinska Institutet JSJonas SchwielerElectrophysiology NWN. Håkan WallénKarolinska Institutet

Discussion

Member takes

Implication

Ang II infusion may promote mild platelet activation in healthy males; hypothesis-generating for thrombotic risk in patients and requires confirmation.

Structured PICO

Does intravenous infusion of angiotensin II activate platelets and coagulation in healthy males?

Population

18 healthy males

Intervention

Intravenous infusion of angiotensin II (10 ng/kg per min)

Outcome

Platelet function and coagulation in vivo (including plasma beta-thromboglobulin levels, P-selectin expression, platelet fibrinogen binding, and platelet aggregability)surrogate

Angiotensin II infusion in healthy males causes mild platelet activation and enhances coagulation, suggesting a potential prothrombotic effect.

Limitations

clinical relevance remains to be clarified

Cite This Study

Larsson et al. (2000) studied this question.

synapsesocial.com/papers/6a908e894aebf474cb342a77 https://doi.org/10.1097/00001721-200001000-00007

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Implication

Ang II infusion may promote mild platelet activation in healthy males; hypothesis-generating for thrombotic risk in patients and requires confirmation.

Platelet activation during angiotensin II infusion in healthy volunteers

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Platelet activation during angiotensin II infusion in healthy volunteers

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider