Key result
Short-term infusion of Angiotensin II increased blood pressure to 146/97 mmHg (p<0.001) but had no effect on PAI-1 activities or plasma concentrations in healthy volunteers.
Why the study?
Does short-term infusion of Angiotensin II affect PAI-1 activities and plasma concentrations in healthy subjects?
Population
9 healthy volunteer subjects
Comparison
Angiotensin II infusion at doses of 1, 3 and 10… vs Baseline / without valsartan pretreatment
Design
Other
Follow-up
45 min per dose
Authors
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Short-term Ang II infusion does not alter PAI-1 in healthy volunteers; leaves open chronic exposure or disease-state effects on fibrinolysis.
Does short-term infusion of Angiotensin II affect PAI-1 activities and plasma concentrations in healthy subjects?
Short-term infusion of Angiotensin II does not acutely alter PAI-1 levels in healthy subjects, suggesting no immediate direct effect on fibrinolytic balance despite significant hemodynamic responses.
Lottermoser et al. (2004) studied Healthy volunteers (n=9). Angiotensin II with or without valsartan vs. Without valsartan pretreatment was evaluated on Activity and antigen concentration of PAI-1. Short-term infusion of Angiotensin II increased blood pressure to 146/97 mmHg (p<0.001) but had no effect on PAI-1 activities or plasma concentrations in healthy volunteers.
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