Key result
Alcohol consumption interacts with rare SMC5 genetic variants to influence triglyceride levels.
Why the study?
Alcohol intake influences plasma lipid levels, but the moderating role of aggregated rare and low-frequency protein-coding variants in gene-alcohol interactions remained to be characterized.
Do rare and low-frequency genetic variants interact with alcohol consumption to influence fasting plasma lipid levels in individuals of European ancestry?
Population
34 153 discovery and 32 277 replication individuals with European ancestry in the CHARGE consortium
Comparison
Current drinker vs non-drinker and regular drinker vs non-regular drinker interactions with aggregated variants
Design
Gene-environment interaction study across 5 discovery and 6 replication cohorts
Authors
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May support SMC5-alcohol interaction on triglycerides; hypothesis-generating and should not yet change practice.
Observational (n=66,430)
Yes
Do rare and low-frequency genetic variants interact with alcohol consumption to influence fasting plasma lipid levels in individuals of European ancestry?
p-value: p=6.65×10−6
Rare and low-frequency genetic variants, particularly in the SMC5 locus, interact with alcohol consumption to influence plasma triglyceride levels.
Wang et al. (2020) conducted an observational in Fasting plasma lipid levels (n=66,430). Alcohol consumption and rare/low-frequency genetic variants was evaluated on Gene-alcohol interaction on triglycerides (p=6.65×10−6). Rare and low-frequency genetic variants interacted with alcohol consumption to influence lipid levels, including a significant interaction on triglycerides at the SMC5 locus (P=6.65×10−6).
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