What question did this study set out to answer?

To identify genetic loci that influence circulating lipid levels through interactions with physical activity across diverse ancestral populations.

January 22, 2019Nature CommunicationsOpen Access

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

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Authors

TKTuomas O. KilpeläinenBroad Institute ABAmy R. BentleyNational Institutes of Health RNRaymond NoordamGeneral / Preventive / Lipids

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Implication

Genome-wide interaction study reveals four genetic loci modifying blood lipid levels alongside exercise across diverse ancestries, highlighting how physical activity modulates genetic...

Key Points

To identify genetic loci that influence circulating lipid levels through interactions with physical activity across diverse ancestral populations.
Conducted genome-wide interaction analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry.
Followed up suggestive gene-by-physical activity interaction associations in an independent cohort of 131,012 individuals.
Identified four loci (in or near CLASP1, LHX1, SNTA1, and CNTNAP2) that significantly interact with physical activity to modify circulating lipid levels.
Higher physical activity enhanced the HDL cholesterol-increasing effects of CLASP1, LHX1, and SNTA1, and attenuated the LDL cholesterol-increasing effect of CNTNAP2.
The identified CLASP1, LHX1, and SNTA1 regions harbor genes with established functional links to muscle function and lipid metabolism.

Cite This Study

Kilpeläinen et al. (2019) studied this question.

synapsesocial.com/papers/6aa14686e90d587b1c3d4683 https://doi.org/10.1038/s41467-018-08008-w

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Implication

Genome-wide interaction study reveals four genetic loci modifying blood lipid levels alongside exercise across diverse ancestries, highlighting how physical activity modulates genetic...

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Discussion

Member takes

Implication

Key Points

Cite This Study

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Discussion

Member takes

Implication

Key Points

Cite This Study

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