Why the study?
Educational attainment, a surrogate for socioeconomic status, predicts cardiovascular health outcomes, but its interactions with genetics in regulating lipids had not been fully characterized.
Population
Up to 226,315 individuals from five population groups
Comparison
Gene-educational attainment interactions across Some College and Graduated College categories
Design
Two-stage genome-wide meta-analysis
Authors
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Identifies 18 novel lipid loci via gene-education interactions; extends genetic architecture of dyslipidemia while leaving clinical translation open.
Genome-wide interaction analysis incorporating educational attainment identified 18 novel lipid loci, highlighting the potential role of brain-adipose-liver communication in lipid metabolism.
Fuentes et al. (2023) studied this question.
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