Key result
Gene-alcohol interaction analysis identifies 18 novel loci linked to lipid levels.
Why the study?
Lipid profiles are influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures had not been studied.
Do gene-alcohol interactions influence lipid levels in a multiancestry population?
Population
394,584 individuals from 5 ancestry groups across 45 stage 1 and 66 stage 2 studies
Comparison
Genetic main effects and gene-alcohol interactions on lipid levels
Design
Two-stage multiancestry genome-wide association study
Authors
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No immediate change to lipid management; leaves open whether gene-alcohol interactions improve genetic risk models in diverse populations.
Observational (n=394,584)
Yes
Do gene-alcohol interactions influence lipid levels in a multiancestry population?
p-value: p=< 5 × 10-8
Incorporating gene-alcohol interactions in a multiancestry GWAS identified 18 novel loci associated with lipid levels, highlighting new genetic contributors to lipid metabolism.
Vries et al. (2019) conducted an observational in Lipid levels (n=394,584). Gene-alcohol interactions was evaluated on Association with lipid levels (HDL, LDL, and triglycerides) (p=< 5 × 10-8). Incorporating gene-alcohol interactions into a multiancestry genome-wide association study identified 147 independent loci associated with lipid levels (P < 5 × 10-8), of which 18 were novel.
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