Why the study?
Alcohol intake influences plasma lipid levels and may be modulated by genetic variants, but the role of aggregated rare and low-frequency variants in gene-alcohol interactions was uncharacterized.
Do rare and low-frequency genetic variants interact with alcohol consumption to influence fasting plasma lipid levels?
Comparison
Current drinker vs non-drinker and regular drinker vs non-regular drinker across rare and low-frequency variants
Design
Gene-environment interaction study across discovery and replication cohorts
Authors
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Gene-alcohol interactions via rare variants on lipids are hypothesis-generating; leaves open clinical translation or targeted interventions.
Do rare and low-frequency genetic variants interact with alcohol consumption to influence fasting plasma lipid levels?
Rare and low-frequency genetic variants, particularly in SMC5, interact with alcohol consumption to influence plasma triglyceride levels.
Wang et al. (2019) studied this question.
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