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June 1, 2017Circulation Cardiovascular GeneticsOpen Access

Multiancestry Study of Gene–Lifestyle Interactions for Cardiovascular Traits in 610 475 Individuals From 124 Cohorts

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Key result

The Gene-Lifestyle Interactions Working Group established a framework to evaluate gene-lifestyle interactions for cardiovascular traits in up to 610,475 individuals from 124 cohorts.

Population

Up to 610,475 individuals from 124 cohorts of multiple ancestries

Design

Other

Authors

DRD. C. RaoTWThomas W. WinklerKSKaren Schwander

Discussion

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Overview

Provides framework for large multiancestry gene-lifestyle meta-analyses; leaves open whether novel cardiovascular loci will emerge.

Study Design

Type

Meta-Analysis (n=610,475)

Multicenter

Yes

Structured PICO

P
Population
Up to 610,475 individuals from 124 cohorts across multiple ancestries evaluated for gene-lifestyle interactions regarding cardiovascular traits.
E
Exposure
Gene-lifestyle interaction analysis evaluating lifestyle factors including smoking, alcohol, education, physical activity, psychosocial variables, and sleep
O
Outcome
Cardiovascular traits including blood pressure and lipidssurrogate

The Gene-Lifestyle Interactions Working Group provides a framework for large-scale multiancestry meta-analyses to identify novel genetic loci for cardiovascular traits through gene-lifestyle interactions.

Limitations

  • Total sample sizes vary among projects because of missing data
  • Large-scale gene-environment interaction meta-analysis studies can be cumbersome and challenging
  • Large-scale gene-lifestyle interaction meta-analysis studies can be cumbersome and challenging

Cite This Study

Rao et al. (2017) conducted a meta-analysis in Cardiovascular traits (blood pressure, lipids) (n=610,475). Gene-lifestyle interactions was evaluated on Cardiovascular traits including blood pressure and lipids. The Gene-Lifestyle Interactions Working Group established a framework to evaluate gene-lifestyle interactions for cardiovascular traits in up to 610,475 individuals from 124 cohorts.

synapsesocial.com/papers/6a9502ca1fe04514d10f38efhttps://doi.org/10.1161/circgenetics.116.001649
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Also Consider

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  1. 1Gene–Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study2014 · 67 citations
  2. 2Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican–Americans2009 · 22 citations
  3. 3Genetic and Environmental Risks for High Blood Pressure Among African American Mothers and Daughters2009 · 35 citations
  4. 4GenABEL: an R library for genome-wide association analysis2007 · 1,991 citations
  5. 5ProbABEL package for genome-wide association analysis of imputed data2010 · 409 citations