Key result
Weight loss and exercise offer potential therapies for underdiagnosed NASH in obesity and T2D.
Why the study?
Non-alcoholic steatohepatitis is an underdiagnosed liver disease with potential progression to cirrhosis and hepatocellular carcinoma, particularly prevalent in obese and type 2 diabetes patients.
This review highlights NASH as a significant, underdiagnosed condition linked to obesity and insulin resistance, emphasizing lifestyle and insulin-sensitizing therapies.
Alerts clinicians to screen obese and T2D patients for NASH; leaves open prospective trials of lifestyle interventions.
Review in Depth 1079 Introduction Peter L.M. Jansen 1087 The epidemiology of fatty liver Stefano Bellantani, Giorgio Bedogni, Lucia Miglioli and Claudio Tiribelli 1095 Mitochondrial injury in steatohepatitis Dominique Pessayre, Bernard Fromenty and Abdellah Mansouri 1107 Role of liver biopsy in the assessment of non-alcoholic fatty liver disease Stefan G. Hübscher 1117 Evaluation and management of non-alcoholic steatohepatitis B. Marie Reid and Arun J. Sanyal Introduction Peter L.M. Jansen Non-alcoholic steatohepatitis (NASH) is an underdiagnosed liver disease characterized by steatosis, necroinflammation and fibrosis. This disease may eventually develop into cirrhosis and hepatocellular carcinoma. NASH is highly prevalent among obese individuals and among patients with diabetes mellitus type 2. Non-alcoholic fatty liver (NAFL), a precursor of NASH, is the main cause of elevated serum liver enzymes among the general population. In NASH the liver is programmed to lipogenesis rather than to glycogenesis and herein insulin-resistance plays a major role. Gradual weight loss, physical exercise and drugs that improve insulin sensitivity are potential therapies.
No takes yet. Share an insight, caveat, or question.
Peter L. M. Jansen (2004) conducted a review in Non-alcoholic steatohepatitis. Non-alcoholic steatohepatitis is an underdiagnosed liver disease highly prevalent among obese individuals and patients with type 2 diabetes, with potential therapies including weight loss and exercise.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: