Key result
Histologic evaluation of liver biopsy remains the gold standard for diagnosing NASH.
Why the study?
Nonalcoholic steatohepatitis (NASH) is the progressive form of NAFLD and requires histologic evaluation for diagnosis, but criteria for diagnosis need clarification.
Histologic evaluation of a liver biopsy remains the gold standard in the diagnosis of NAFLD/NASH.
Requires histologic confirmation for NASH diagnosis in practice; leaves open validation of noninvasive alternatives in research.
Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of histologic changes characterized by varying degrees of steatosis, inflammation, hepatocellular injury, and fibrosis in liver. Nonalcoholic steatohepatitis (NASH) is the progressive form of NAFLD. These entities are the hepatic manifestations of insulin resistance syndrome, and are associated with obesity, type II diabetes, and hyperlipidemia. At this time, histologic evaluation of a liver biopsy remains the gold standard in the diagnosis of NAFLD/NASH. This review will discuss the criteria that are important for the histologic diagnosis of NASH.
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Liu et al. (2010) conducted a review in Nonalcoholic steatohepatitis (NASH). Histologic evaluation of a liver biopsy remains the gold standard for the diagnosis of nonalcoholic steatohepatitis (NASH).
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