Key result
Severe carotid calcification reduces PSV sensitivity for detecting ≥70% stenosis to 90%.
Why the study?
The study evaluated the effect of calcified lesions on peak systolic velocity when diagnosing internal carotid artery stenosis using carotid ultrasound.
Does severe calcification affect the diagnostic accuracy of peak systolic velocity for detecting internal carotid artery stenosis?
Cross-Sectional (n=149)
No
Does severe calcification affect the diagnostic accuracy of peak systolic velocity for detecting internal carotid artery stenosis?
Absolute Event Rate: 90% vs 100%
Severe calcification (≥50% of vessel circumference) reduces the diagnostic accuracy of peak systolic velocity for detecting ≥70% internal carotid artery stenosis due to acoustic shadowing and altered hemodynamics.
May warrant caution interpreting peak systolic velocity in calcified vessels; leaves open need for validated alternatives or adjusted thresholds.
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Kuriki et al. (2019) conducted a cross-sectional in Internal carotid artery stenosis (n=149). Severe carotid calcification (≥50% perivascular calcification) vs. Mild or no calcification (<50% perivascular calcification) was evaluated on Sensitivity to detect NASCET stenosis ≥70% using peak systolic velocity ≥200 cm/sec. Severe carotid calcification reduced the sensitivity and specificity of peak systolic velocity (≥200 cm/sec) for detecting ≥70% internal carotid artery stenosis to 90.0% and 75.4%, compared to 100% and 90.2% in vessels without severe calcification.
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