Key result
Lymphoma irradiation is linked to transient ECG and blood pressure changes resolving after 6 months.
Why the study?
The cardiovascular effects of irradiation for malignant lymphoma during and after treatment were not well characterized.
Does irradiation for malignant lymphoma cause cardiovascular changes in patients?
Observational (n=55)
Does irradiation for malignant lymphoma cause cardiovascular changes in patients?
Irradiation for malignant lymphoma induces transient cardiovascular changes, notably blood pressure reduction and ECG abnormalities, which resolve within 6 months.
May reassure on short-term recovery after lymphoma irradiation; leaves open long-term risks with modern regimens.
In 55 patients irradiated for malignant lymphoma the complaints were recorded as well as ECG, blood pressure, exercise test and heart volume before, during and one and 6 months following treatment. ECG abnormalities and fall in blood pressure occurred during treatment. Reduced physical working capacity was found one month after treatment. After 6 months all parameters had returned to pretreatment levels. Attention should be paid to the considerable reduction in blood pressure that does occur in some cases during treatment.
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Larsson et al. (1976) conducted an observational in Malignant lymphoma (n=55). Irradiation vs. Pretreatment levels was evaluated on ECG, blood pressure, exercise test and heart volume. Irradiation for malignant lymphoma caused transient ECG abnormalities, blood pressure reduction, and reduced physical working capacity that returned to pretreatment levels after 6 months.
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