Key result
Hyperfibrinogenemia shows no effect on atherosclerotic lesion initiation or early progression in mice.
Why the study?
Elevated fibrinogen is correlated with severe atherosclerosis, but the mechanistic basis for this correlation remains unknown.
Does hyperfibrinogenemia or an atherogenic diet affect the initiation and progression of atherosclerotic lesions in C57BL/6 mice?
Population
Normal and transgenic C57BL/6 mice with hyperfibrinogenemia
Comparison
Atherogenic diet vs simple breeder chow
Design
Preclinical study
Follow-up
8 to 12 months
Authors
Loading...
No effect on early lesions in mice; leaves open fibrinogen's role in advanced atherosclerosis or humans.
Does hyperfibrinogenemia or an atherogenic diet affect the initiation and progression of atherosclerotic lesions in C57BL/6 mice?
In a mouse model, elevated fibrinogen levels did not significantly affect the initiation or early progression of atherosclerotic lesions, suggesting hyperfibrinogenemia may not be a direct causal factor in early atherogenesis.
Gulledge et al. (2003) studied Atherosclerosis. Hyperfibrinogenemia (transgenic genotype) and atherogenic diet vs. Normal genotype and simple breeder chow was evaluated on Initiation, initial growth, or early progression of atherosclerotic lesions (number and size). Hyperfibrinogenemia in transgenic mice had no statistically significant effect on the initiation, initial growth, or early progression of atherosclerotic lesions compared to normal mice.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: