Key result
Amipaque limits hemodynamic drops and reduces chest pain versus Isopaque Coronar during coronary angiography.
Why the study?
A comparative evaluation of Isopaque Coronar and Amipaque (metrizamide) in coronary angiography was needed to assess safety and efficacy differences.
Does Amipaque improve hemodynamic stability and patient comfort compared to Isopaque Coronar in patients undergoing selective coronary angiography?
RCT (n=39)
Double-blind
Does Amipaque improve hemodynamic stability and patient comfort compared to Isopaque Coronar in patients undergoing selective coronary angiography?
Amipaque (metrizamide) provides better hemodynamic stability and patient comfort compared to Isopaque Coronar during selective coronary angiography, with equivalent image quality.
Answers are grounded in this paper and cite their sources.
Amipaque may be preferred to minimize hemodynamic instability and discomfort in coronary angiography; extends RCT evidence for low-osmolar agents.
Isopaque Coronar and Amipaque (metrizamide) were evaluated in a comparative double-blind study of 30 patients with heart disease undergoing selective coronary angiography. Amipaque alone was also used for 9 additional patients undergoing left ventriculography, aortic root injection, and selective coronary angiography. Amipaque resulted in significantly less of a decrease in diastolic pressure and heart rate, reduced chest pain and heat sensation, and longer coronary contrast transit time. Electrorocardiographic parameters and image quality were equivalent with the 2 agents. No pathological changes were noted in the 9 patients undergoing complete angiocardiographic study.
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Enge et al. (1977) conducted an RCT in Heart disease (n=39). Amipaque (metrizamide) vs. Isopaque Coronar was evaluated on Hemodynamic changes, symptoms, and image quality. Amipaque resulted in significantly less decrease in diastolic pressure and heart rate, and reduced chest pain and heat sensation compared to Isopaque Coronar during coronary angiography.
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