Key result
Ozaki procedure linked to lower aortic pressure gradients and larger effective orifice areas than bioprostheses.
Why the study?
Does aortic valve reconstruction using autologous pericardium (Ozaki procedure) improve immediate echocardiographic characteristics compared to frame-mounted biological prostheses in patients requiring aortic valve replacement?
Cohort (n=96)
No
Does aortic valve reconstruction using autologous pericardium (Ozaki procedure) improve immediate echocardiographic characteristics compared to frame-mounted biological prostheses in patients requiring aortic valve replacement?
p-value: p=<0.001
The Ozaki procedure provides superior immediate hemodynamic performance compared to standard frame-mounted biological prostheses for aortic valve replacement.
Small single-center echocardiographic comparison of Ozaki reconstruction versus bioprostheses offers no clinical guidance; leaves open need for randomized durability trials.
Aim. The study was designed to compare the immediate echocardiographic characteristics of aortic valve reconstruction by using autologous pericardium and the method proposed in 2007 by Shigeyuki Ozaki, as well as aortic valve replacement by means of frame-mounted biological prostheses Medtronic HANCOCK®II T505 CINCH® II and the Carpentier-Edwards PERIMOUNT. Methods. Over a period from January 2014 to February 2016, 76 patients underwent aortic valve replacement by means of frame-mounted biological prostheses Medtronic HANCOCK®II T505 CINCH® II (n=41) and Carpentier-Edwards PERIMOUNT (n=35) at our hospital. 20 patients underwent the Ozaki procedure. These three groups of patients were assigned to the study. Demographic and preoperative indicators of patients from all three groups were homogeneous (р>0.05). The evaluation of the aortic valves replaced was carried out by echocardiography. Results. Echocardiography was performed before the procedure and in the early postoperative period. Statistical analysis using ANOVA showed significantly lower values of the aortic valve pressure gradient (p<0.001) and larger effective orifice area and indexed effective orifice area of the valve (p<0.001) in the group of the Ozaki procedure. Conclusion. According to echocardiography data, in the immediate postoperative period the Ozaki procedure is associated with lower mean and peak gradients of pressure on the aortic valve and larger effective orifice area and indexed effective orifice area of the valve, as compared with the frame-mounted biological aortic prostheses Medtronic HANCOCK®II T505 CINCH® II and the Carpentier-Edwards PERIMOUNT. Received 27 May 2016. Accepted 24 June 2016. Funding: The study had no sponsorship. Conflict of interest: The authors declare no conflict of interest.
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Rosseykin et al. (2016) conducted a cohort in Aortic valve disease requiring replacement (n=96). Aortic valve reconstruction using autologous pericardium (Ozaki procedure) vs. Aortic valve replacement with frame-mounted biological prostheses (Medtronic HANCOCK II and Carpentier-Edwards PERIMOUNT) was evaluated on Immediate echocardiographic characteristics (aortic valve pressure gradient and effective orifice area) (p=<0.001). Aortic valve reconstruction using the Ozaki procedure was associated with significantly lower aortic valve pressure gradients and larger effective orifice areas than biological prostheses (p<0.001).
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