Key result
Betaxolol provides effective 24-hour control of blood pressure and heart rate.
Betaxolol is a long-acting beta1-selective blocker that provides 24-hour blood pressure and heart rate control.
May support once-daily betaxolol for hypertension; leaves open need for randomized comparative trials.
Betaxolol (Searle, Skokie, Illinois) is a new beta 1-selective adrenergic blocker with no partial agonist action and minimal membrane stabilizing activity. Its pharmacokinetic profile is characterized by a long serum half-life and excellent oral bioavailability, with little first-pass metabolism. The mean 16-hour half-life of betaxolol has been shown to provide full 24-hour control of blood pressure and heart rate. Betaxolol has been proven to be a safe and effective antihypertensive agent, and was recently approved for clinical use in the United States for this indication.
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Frishman et al. (1990) conducted a review in Hypertension. Betaxolol was evaluated. Betaxolol, a beta1-selective adrenergic blocker with a mean 16-hour half-life, provides full 24-hour control of blood pressure and heart rate and is an effective antihypertensive agent.
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