Key result
Strategies targeting myocardial energy demand and supply yield no accepted routine method to reduce infarct size.
Why the study?
Do approaches such as reducing myocardial energy demands, stimulating glycolysis, or reperfusion effectively reduce infarct size in humans with acute myocardial infarction?
Population
Patients with acute myocardial infarction and animal models
Design
Review
Authors
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No accepted infarct size reduction strategy exists in AMI; leaves open translation of experimental cardioprotection to clinical trials.
Do approaches such as reducing myocardial energy demands, stimulating glycolysis, or reperfusion effectively reduce infarct size in humans with acute myocardial infarction?
Translating experimental successes in reducing infarct size into routine clinical practice for patients with acute myocardial infarction remains a significant challenge.
Kübler et al. (1985) conducted a review in acute myocardial infarction. Infarct size reduction strategies was evaluated. Despite extensive research on reducing myocardial energy demands or increasing supply, there is no generally accepted method for reducing infarct size available for routine clinical use.
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