Key result
Prolonged cardiopulmonary bypass and aortic cross-clamp times are linked to increased post-surgical morbidity.
Why the study?
The study was conducted to determine the impact of cardiopulmonary bypass time and aortic cross-clamp time on immediate postoperative outcomes in patients with congenital heart disease undergoing open heart surgery.
Does increased cardiopulmonary bypass time and aortic cross-clamp time worsen immediate post-operative outcomes in patients with congenital heart disease undergoing open heart surgery?
Observational (n=104)
No
Does increased cardiopulmonary bypass time and aortic cross-clamp time worsen immediate post-operative outcomes in patients with congenital heart disease undergoing open heart surgery?
p-value: p=<0.001
Increased cardiopulmonary bypass and aortic cross-clamp times are significantly associated with higher immediate post-surgical morbidity in patients undergoing congenital heart surgery.
May warrant minimizing bypass and clamp times in congenital repairs; leaves open causal confirmation in prospective trials.
Objective: to find out the impact of cardiopulmonary bypass time (CPBT) and aortic cross-clamp time (ACCT) on immediate post-operative outcomes in patients with congenital heart disease (CHD) undergoing open heart surgery at a tertiary care centre. Study Design: Prospective longitudinal study. Place and Duration of the Study: Department of Paediatric, Cardiac Intensive Care Unit, National Institute of Cardiovascular Diseases (NICVD), Karachi Pakistan, from Jul to Dec 2021. Methodology: We enrolled 104 patients of both genders up to any age with CHD undergoing open heart surgeries. At the time of admission, age, gender, body weight, presence of cyanosis and types of CHDs were noted. Duration of mechanical ventilation, pediatric cardiac intensive care unit (PCICU) stay, and mortality was recorded. Baseline characteristics and postsurgery parameters were compared about CPBT and ACCT. Results: Of 104 patients, 58(55.8%) were males. Overall, the mean age was 7.9±5.1 years. Cyanosis was noted in 34(32.7%) cases. Mean CPBT was 74.6±42.9 minutes, while the mean ACCT was 43.5±29.5 minutes. Most types of CHDs were noted to be tetralogy of Fallot (ToF) 28(26.9%). An increase in the duration of CPBT and ACCT was found to have a significant association with post-surgical morbidity (p<0.001). Conclusion: Increased cardiopulmonary bypass time and aortic cross-clamp time were found to have a significant association with post-surgical morbidity and outcomes among cases undergoing open heart surgeries for congenital heart diseases.
No takes yet. Share an insight, caveat, or question.
Alisher et al. (2023) conducted an observational in Congenital Heart Disease (n=104). Prolonged cardiopulmonary bypass time and aortic cross-clamp time vs. Normal cardiopulmonary bypass time and aortic cross-clamp time was evaluated on Post-surgical morbidity (p=<0.001). Prolonged cardiopulmonary bypass time and aortic cross-clamp time were significantly associated with increased post-surgical morbidity and adverse outcomes (p<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: