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September 1, 2009Perfusion

Safe time limits of aortic cross-clamping and cardiopulmonary bypass in adult cardiac surgery

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Why the study?

What are the safe time limits of aortic cross-clamping and cardiopulmonary bypass to prevent 30-day mortality and morbidity in adult cardiac surgery?

Population

3,280 patients who underwent adult cardiac surgery of various complexities, with myocardial protection…

Comparison

Aortic cross-clamping time and cardiopulmonary… vs Different time intervals

Design

Cohort

Follow-up

30-day

Authors

JNJuha NissinenFBFausto BiancariJWJan-Ola Wistbacka

Discussion

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Member takes

Overview

XCT >150 min or CPBT >240 min was associated with higher 30-day mortality; leaves open whether minimizing these times improves outcomes.

Structured PICO

What are the safe time limits of aortic cross-clamping and cardiopulmonary bypass to prevent 30-day mortality and morbidity in adult cardiac surgery?

P
Population
3,280 patients who underwent adult cardiac surgery of various complexities, with myocardial protection achieved via tepid continuous antegrade/retrograde blood cardioplegia
I
Intervention
Aortic cross-clamping time (XCT) and cardiopulmonary bypass time (CPBT)
C
Comparator
Different time intervals (XCT <150 min vs ≥150 min; CPBT <240 min vs ≥240 min)
O
Outcome
30-day postoperative mortalityhard clinical

Aortic cross-clamping time >150 minutes and cardiopulmonary bypass time >240 minutes are independent predictors of significantly increased 30-day mortality and morbidity in adult cardiac surgery.

Cite This Study

Nissinen et al. (2009) studied this question.

synapsesocial.com/papers/6a70a4f2e71d69abee08c01dhttps://doi.org/10.1177/0267659109354656
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Does the Duration of Cardiopulmonary Bypass or Aortic Cross-Clamp, in the Absence of Blood and/or Blood Product Administration, Influence the IL-6 Response to Cardiac Surgery?1998 · 65 citations
  2. 2Does the Duration of Cardiopulmonary Bypass or Aortic Cross-Clamp, in the Absence of Blood and/or Blood Product Administration, Influence the IL-6 Response to Cardiac Surgery?1998 · 63 citations
  3. 3Is blood cardioplegia superior to crystalloid cardioplegia?2008 · 84 citations
  4. 4The logistic EuroSCORE2003 · 1,150 citations
  5. 5Risk stratification in paediatric open-heart surgery12004 · 95 citations