Key result
Pure submaxillary gland renin sustainably raises BP and generates angiotensin in nephrectomized rats.
Why the study?
The effects of pure submaxillary gland renin on blood pressure and its enzymatic action on plasma renin substrate were studied to characterize its properties.
Population
Nephrectomized rats and plasma renin substrate from multiple species
Comparison
Administration of subnanogram quantities of pure submaxillary gland renin vs no administration
Design
Preclinical experimental study
Authors
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Animal data link purified renin to sustained BP elevation; leaves open translation to human hypertension or therapeutics.
Pure submaxillary gland renin causes a sustained rise in blood pressure in nephrectomized rats and generates angiotensin from plasma renin substrate.
Michelakis et al. (1974) studied this question. Pure submaxillary gland renin was evaluated on Blood pressure and angiotensin generation. Administration of pure submaxillary gland renin to nephrectomized rats caused a sustained rise in blood pressure and generated angiotensin from plasma renin substrate across multiple species.
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