Reimplantation linked to ~66% lower late mortality vs. remodeling for aortic root aneurysms.
Why the study?
Valve-sparing aortic root replacement is an important treatment for aortic root aneurysms, but outcomes between reimplantation and remodeling techniques needed evaluation.
Does the reimplantation technique reduce mortality and reoperation compared to the remodeling technique in patients undergoing valve-sparing surgery for aortic root aneurysms?
Comparison
Reimplantation vs remodeling techniques
Design
Systematic review and meta-analysis of retrospective cohort studies
Key result
The reimplantation technique for aortic root aneurysms was associated with a significantly lower risk of late mortality compared with remodeling (RR 0.34; 95% CI 0.17-0.71; P=0.004).
Authors
Discussion
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Member takes
Overview
May support reimplantation preference in valve-sparing root repair; leaves open confirmation by randomized trials.
Study Design
Type
Meta-Analysis (n=1,672)
Structured PICO
Does the reimplantation technique reduce mortality and reoperation compared to the remodeling technique in patients undergoing valve-sparing surgery for aortic root aneurysms?
P
Population
1,672 patients with aortic root aneurysms from 14 retrospective cohort studies comparing reimplantation (n=1,011) versus remodeling (n=661) techniques.
I
Intervention
Reimplantation technique for valve-sparing aortic root replacement (n=1,011)
C
Comparator
Remodeling technique for valve-sparing aortic root replacement (n=661)
O
Outcome
Early mortality, late mortality, aortic valve-related reoperation, and postoperative moderate to severe aortic regurgitation (AR)hard clinical
Main Result
Relative Risk: 0.34 (95% CI 0.17–0.71)
p-value: p=0.004
In patients undergoing valve-sparing surgery for aortic root aneurysms, the reimplantation technique is associated with significantly lower risks of late mortality and reoperation compared to the remodeling technique.
Cite This Study
Zhou et al. (2020) conducted a meta-analysis in Aortic root aneurysms (n=1,672). Reimplantation technique vs. Remodeling technique was evaluated on Late mortality (RR 0.34, 95% CI 0.17-0.71, p=0.004). The reimplantation technique for aortic root aneurysms was associated with a significantly lower risk of late mortality compared with remodeling (RR 0.34; 95% CI 0.17-0.71; P=0.004).