Key result
Solid left atrial myxomas are linked to ~4x more CHF presentations than embolic-prone papillary types.
Why the study?
Most case series on atrial myxoma have focused on clinical presentation rather than correlating gross and microscopic tumor features with clinical manifestations.
Do different morphologic types of left atrial myxoma (papillary vs. solid) present with different clinical features?
Population
68 patients with left atrial myxoma
Comparison
Soft (papillary) tumor vs solid tumor in the left atrium
Design
Observational cohort study
Follow-up
In-hospital
Authors
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Morphologic classification of atrial myxoma may refine clinical correlation; leaves open confirmation in larger prospective cohorts.
Observational (n=68)
No
Do different morphologic types of left atrial myxoma (papillary vs. solid) present with different clinical features?
Absolute Event Rate: 92% vs 22.2%
p-value: p=< 0.001
The gross morphologic type and location of left atrial myxomas (solid vs. papillary) predict their clinical presentation, with solid tumors more often causing fever, heart failure, and dyspnea.
Rahman et al. (2015) conducted an observational in Left atrial myxoma (n=68). Solid left atrial myxoma vs. Papillary left atrial myxoma was evaluated on Presentation with congestive heart failure (CHF) (p=< 0.001). Solid left atrial myxomas predominantly presented with congestive heart failure (92% vs 22.2%, p<0.001), while papillary myxomas were significantly more likely to present with neurologic and embolic events.
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