Key result
Captopril plus nitroglycerin is linked to a ~19% higher response rate in hypertensive emergencies.
Why the study?
This study evaluated the efficacy of captopril combined with nitroglycerin injection on complication rates and blood pressure control in hypertensive emergency patients.
Does captopril combined with nitroglycerin injection improve blood pressure control and reduce complications in hypertensive emergency patients compared to nitroglycerin alone?
Does captopril combined with nitroglycerin injection improve blood pressure control and reduce complications in hypertensive emergency patients compared to nitroglycerin alone?
The addition of captopril to nitroglycerin injection in hypertensive emergencies may improve blood pressure control and reduce complications compared to nitroglycerin alone.
Answers are grounded in this paper and cite their sources.
Supports captopril addition in hypertensive emergency; hypothesis-generating and requires randomized trials before practice change.
This study focuses on the efficacy of captopril combined with nitroglycerin injection on complication rate and blood pressure control in hypertensive emergency patients. 115 hypertensive emergency patients admitted between December, 2018 and December, 2022 were selected and divided into two groups in which 59 patients received captopril combined with nitroglycerin injection (research group) and 56 patients received nitroglycerin injection (control group). The curative effect, complication rate (vomiting, cough, increased heart rate, tinnitus, dizziness and pulsatile headache), blood pressure control (systolic and diastolic blood pressure), glucolipid metabolism (total cholesterol, triglyceride and fasting plasma glucose) and neurological function (based on National Institutes of Health Stroke Scale scores) were analyzed and compared. Evidently higher overall response and fewer complications were determined in the research group compared with the control group. The research group also showed notably lower post-treatment systolic, diastolic blood pressure, total cholesterol, triglyceride, fasting plasma glucose and National Institutes of Health Stroke Scale score than the control group. The above result shows that captopril combined with nitroglycerin injection can enhance efficacy in hypertensive emergency patients and is more conducive to blood pressure control with better clinical safety and efficacy.
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Fei Liu (2024) studied Hypertensive Emergency (n=115). Captopril combined with nitroglycerin injection vs. Nitroglycerin injection was evaluated on Overall Response Rate (ORR) (p=0.03). Captopril combined with nitroglycerin injection significantly improved the overall response rate to 91.53% compared to 76.79% with nitroglycerin alone in patients with hypertensive emergency.
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