Key result
COPD and asthma are linked to higher AF risk, with COPD showing ~74% greater risk.
Why the study?
Respiratory diseases involving chronic pulmonary ventilation dysfunction are mainly composed of COPD and asthma, motivating an evaluation of their association with atrial fibrillation risk.
Does COPD or asthma increase the risk of atrial fibrillation?
Meta-Analysis
Does COPD or asthma increase the risk of atrial fibrillation?
Relative Risk: 1.74 (95% CI 1.7–1.79)
Both COPD and asthma are significantly associated with an increased risk of developing atrial fibrillation, highlighting the need for AF screening in patients with chronic pulmonary ventilation dysfunction.
COPD or asthma may raise AF risk; leaves open whether screening or risk modification improves outcomes.
Background: Respiratory diseases related to chronic pulmonary ventilation dysfunction are mainly composed of chronic obstructive pulmonary disease (COPD) and asthma. Our meta-analysis aimed to illustrate the association of COPD or asthma with risk of atrial fibrillation (AF). Methods: We systematically searched the databases of the PubMed, Embase, and Cochrane library until December 2021 for studies focusing on the relationship between COPD or asthma and AF risk. Due to the potential heterogeneity across studies, the random-effects model was used to pool the studies. Results: Our meta-analysis included 14 studies. Based on the random-effects model, the pooled analysis showed that COPD (risk ratio[RR] = 1.74, 95% confidence interval [CI]: 1.70-1.79) and asthma (RR = 1.08, 95% CI: 1.04-1.12) were significantly associated with an increased risk of AF. The results did not change after each study was excluded. Conclusion: Our current data suggested that COPD or asthma with associated with an increased risk of AF.
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Xue et al. (2022) conducted a meta-analysis in COPD or asthma. COPD or asthma vs. Patients without COPD or asthma was evaluated on Risk of atrial fibrillation (RR 1.74, 95% CI 1.70-1.79). COPD and asthma were significantly associated with an increased risk of atrial fibrillation, with COPD showing a risk ratio of 1.74 and asthma a risk ratio of 1.08.
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