Key result
Chronic ischemic cerebrovascular disease associates with impaired circulatory reflexes, but age is a stronger driver.
Why the study?
Circulatory reflex function in subjects with chronic ischaemic cerebrovascular disease and its variation by vascular territory was not well characterized.
Does chronic ischaemic cerebrovascular disease impair circulatory reflex function compared to controls?
Case-Control
Does chronic ischaemic cerebrovascular disease impair circulatory reflex function compared to controls?
Age appears to be a more significant determinant of circulatory reflex impairment than the presence or specific vascular territory of chronic cerebrovascular disease.
Age may outweigh cerebrovascular disease in circulatory reflex impairment; hypothesis-generating and should not yet change practice.
Circulatory reflex function was assessed in a series of subjects with chronic ischaemic cerebrovascular disease and compared with a group of subjects with no known cerebrovascular disease by intra-arterial pressure responses to Valsalva's manoeuvre. 2. Circulatory reflexes were impaired in the patients with cerebrovascular disease as compared with controls, but statistical analysis indicated that age was a more important factor than chronic cerebrovascular disease in producing the deterioration. 3. No significant difference was found in the circulatory reflex function of subjects with ischaemia in the internal carotid territory when compared with those having ischaemia in the vertebrobasilar territory. 4. Combined ischaemia in both carotid and vertebrobasilar territories significantly impaired the cardioaccelerator but not the vasoconstrictor response to Valsalva's manoeuvre. 5. No significant difference was found in circulatory reflex function in subjects who had suffered cerebral infarction as opposed to transient ischaemic attacks.
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M. Melissa Gross (1970) conducted a case-control in chronic ischaemic cerebrovascular disease. Chronic ischaemic cerebrovascular disease vs. No known cerebrovascular disease was evaluated on Circulatory reflex function assessed by intra-arterial pressure responses to Valsalva's manoeuvre. Chronic ischaemic cerebrovascular disease was associated with impaired circulatory reflexes compared to controls, but age was a more important factor in producing the deterioration.
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