Key result
Arterial irrigation at 100 mmHg or greater causes endothelial and elastic lamina injury in rabbits.
Why the study?
The direct effect of irrigation pressure on vessel wall injury during microsurgery was not well characterized.
Does high irrigation pressure cause vessel injury in rabbit arteries?
Does high irrigation pressure cause vessel injury in rabbit arteries?
Controlling microsurgical irrigation pressure to less than 100 mmHg may help to avoid vessel injury during microsurgery.
Answers are grounded in this paper and cite their sources.
May support limiting irrigation pressure below 100 mmHg in microsurgery; leaves open translation from rabbit model to clinical practice.
Irrigation solution is routinely used in microsurgery. While the anticoagulation solution may aid in anastomotic patency, the direct effect of pressure irrigation can have a detrimental effect on the vessel. An experimental study was performed to determine the effect of irrigation pressure on the vessel wall. Histological evaluation with hematoxylin and eosin (H&E) stain and scanning electron microscopy (SEM) was performed on the arteries of New Zealand white rabbits irrigated with lactated Ringer's solution at pressures of 80 mmHg, 100 mmHg, and 500 mmHg. H&E staining and SEM microscopy demonstrated injury to the endothelial cells and internal elastic lamina at pressures of 100 mmHg or greater. Controlling microsurgical irrigation pressure to less than 100 mmHg may help to avoid vessel injury.
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Yan et al. (2004) studied Vessel injury during microsurgery. Irrigation pressure ≥100 mmHg vs. Irrigation pressure of 80 mmHg was evaluated on Injury to the endothelial cells and internal elastic lamina. Irrigation of rabbit arteries at pressures of 100 mmHg or greater caused injury to the endothelial cells and internal elastic lamina.
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