Key result
Norepinephrine reduces proximal iliac arterial compliance by ~35% versus baseline in pigs.
Why the study?
The study aimed to determine the basal vasomotor tone in large conductance arteries and whether their compliance can be altered in vivo by vasoactive agents in a common animal preparation.
Do local infusions of adenosine and norepinephrine alter proximal iliac arterial compliance in pentobarbital-anesthetized pigs?
Do local infusions of adenosine and norepinephrine alter proximal iliac arterial compliance in pentobarbital-anesthetized pigs?
Absolute Event Rate: 13% vs 20%
p-value: p=< 0.01
Intravascular ultrasound can continuously monitor pharmacologically induced changes in large artery compliance, demonstrating that norepinephrine significantly decreases compliance in pentobarbital-anesthetized pigs.
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Should not change practice; leaves open translational relevance of norepinephrine effects on arterial compliance.
Wilson et al. (1995) studied Animal model (pentobarbital-anesthetized pigs) (n=7). Adenosine and norepinephrine infusions vs. Baseline control was evaluated on Proximal iliac arterial compliance (slope of the area/pressure regression line) (p=< 0.01). In pentobarbital-anesthetized pigs, norepinephrine significantly decreased proximal iliac arterial compliance compared to baseline (13 vs 20 mm2/mmHg x 10(-3), P<0.01).
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