Why the study?
Does pentobarbital affect the contraction of vascular smooth muscle in isolated rat aortic strips and portal veins?
Population
Isolated rat aortic strips and portal veins
Design
Preclinical
Authors
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May depress vascular tone in rat models; leaves open translation to human anesthesia.
Does pentobarbital affect the contraction of vascular smooth muscle in isolated rat aortic strips and portal veins?
Pentobarbital at anesthetic concentrations exerts profound depressant effects on vascular smooth muscle contraction, likely by interfering with calcium movement.
Altura et al. (1975) studied this question.
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