Key result
Thiopental induces biphasic cerebrovascular responses, with vasoconstriction driven by intracellular calcium movement.
Why the study?
The mechanism of vascular responsiveness to barbiturates, especially thiopental, in isolated canine basilar arteries was not fully understood.
Population
Isolated and perfused canine basilar arteries
Comparison
Responses to five barbiturates with or without pretreatments (phentolamine, ketanserin, diltiazem, saponin)
Design
Experimental study on isolated arteries
Authors
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Thiopental may alter cerebral hemodynamics in neurosurgery; leaves open clinical relevance of barbiturate choice in humans.
Thiopental-induced vasoconstriction in canine basilar arteries does not involve adrenergic or serotonergic mechanisms and is likely due to intracellular movement of calcium ions.
Tsuji et al. (1987) studied Isolated canine basilar arteries. Thiopental and other barbiturates was evaluated on Vascular response (vasoconstriction and vasodilatation). Thiopental induced a biphasic vascular response in canine basilar arteries, with vasoconstriction likely due to intracellular calcium movement rather than adrenergic or serotonergic mechanisms.
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