Key result
IV pentobarbital triggers tachycardia and lowers stroke volume, whereas thiamylal increases vascular resistance in dogs.
Why the study?
What are the pulmonary and systemic haemodynamic effects of intravenously administered thiamylal and pentobarbital in dogs?
Population
Intact, unsedated, instrumented dogs
Comparison
Intravenously administered thiamylal vs pentobarbital
Design
Preclinical haemodynamic study
Authors
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Anesthetic-specific hemodynamics in canine models may confound experimental interpretation; leaves open translation to human cardiovascular research.
What are the pulmonary and systemic haemodynamic effects of intravenously administered thiamylal and pentobarbital in dogs?
Intravenous pentobarbital and thiamylal induce distinct systemic and pulmonary haemodynamic changes in unsedated dogs.
Goldberg et al. (1968) studied this question. Thiamylal and pentobarbital was evaluated on Pulmonary and systemic haemodynamic effects. Intravenous pentobarbital produced tachycardia and decreased stroke volume, while thiamylal increased systemic and pulmonary vascular resistance in unsedated dogs.
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