Why the study?
Does acute alpha- or combined alpha/beta-adrenoreceptor blockade improve aortic compliance in patients with essential hypertension?
Does acute alpha- or combined alpha/beta-adrenoreceptor blockade improve aortic compliance in patients with essential hypertension?
Sympathetic nervous system activity influences aortic compliance, and alpha-blocking drugs can acutely improve aortic compliance in essential hypertension.
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Acute alpha-blockade should not yet change hypertension practice; hypothesis-generating for sympathetic modulation of aortic rigidity pending RCTs.
Alicandri et al. (1980) studied this question.
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