Key result
Aortic compliance was lower in hypertensive subjects (0.80 ml/mm Hg) than in normotensive subjects (1.47 ml/mm Hg), but increased to equal or greater levels during nitroprusside infusion.
Why the study?
Does nitroprusside infusion improve aortic compliance in hypertensive subjects compared to normotensive controls?
Population
Normotensive and hypertensive Chinese subjects undergoing diagnostic cardiac catheterization
Comparison
Nitroprusside infusion during diagnostic cardiac… vs Baseline conditions and normotensive control…
Design
Cross-sectional
Authors
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Nitroprusside may acutely restore aortic compliance in hypertension; hypothesis-generating for reversible smooth muscle tone contribution.
Observational
Does nitroprusside infusion improve aortic compliance in hypertensive subjects compared to normotensive controls?
Absolute Event Rate: 0.8% vs 1.47%
Aortic compliance is reduced in hypertensive patients partly due to excess smooth muscle tone, which can be reversed with nitroprusside infusion.
Liu et al. (1989) conducted an observational in Hypertension. Hypertension vs. Normotension was evaluated on Aortic compliance under baseline conditions (ml/mm Hg). Aortic compliance was lower in hypertensive subjects (0.80 ml/mm Hg) than in normotensive subjects (1.47 ml/mm Hg), but increased to equal or greater levels during nitroprusside infusion.
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