Key result
21 days of head-down bed rest reduces orthostatic tolerance by ~8 minutes, increasing presyncopal adrenomedullin.
Why the study?
Does bedrest immobilization increase the rise in adrenomedullin and galanin during orthostatic challenge leading to presyncope in healthy men?
Population
8 healthy men
Comparison
21 days of -6° head-down bed rest (HDBR) vs Pre-HDBR (baseline before bed rest)
Design
Other
Follow-up
21 days
Authors
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May link prolonged bed rest to orthostatic intolerance via adrenomedullin; leaves open translation to clinical immobilization or countermeasures.
Does bedrest immobilization increase the rise in adrenomedullin and galanin during orthostatic challenge leading to presyncope in healthy men?
Mean Difference: -8.36
p-value: p=0.0032
Bedrest immobilization increases adrenomedullin levels at presyncope, which may contribute to reduced orthostatic capacity.
O’Shea et al. (2015) studied Healthy (n=8). Head-down bed rest (HDBR) vs. Pre-HDBR (baseline) was evaluated on Orthostatic tolerance time (time from head-up tilt to presyncope) (MD -8.36, p=0.0032). 21 days of head-down bed rest significantly reduced orthostatic tolerance time by 8.36 minutes (P=0.0032) and increased presyncopal adrenomedullin concentrations (P<0.001) in healthy men.