Why the study?
Does orthostasis (passive head-up tilt) increase plasma adrenomedullin concentration in normotensive subjects?
Population
Normotensive subjects
Comparison
Passive head-up tilt for 30 minutes at 12… vs Remain supine
Design
RCT, Randomized to undergo for 30 minutes either 12 degrees, 30 degrees, 53…
Follow-up
Up to 50 minutes after orthostasis
Authors
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Adrenomedullin rises with orthostatic tilt, supporting a compensatory role in hemodynamic stabilization; extends causal evidence to normotensives.
Does orthostasis (passive head-up tilt) increase plasma adrenomedullin concentration in normotensive subjects?
Plasma adrenomedullin rapidly increases in a stimulus-dependent manner during orthostatic challenge, suggesting a role in hemodynamic stabilization.
Rössler et al. (1999) studied this question.
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