What question did this study set out to answer?

Evaluate physiological and sleep responses to a modest bedtime dose of caffeine in habitual coffee drinkers compared to noncoffee drinkers.

January 1, 1968Clinical Pharmacology & Therapeutics

The tolerance of coffee drinkers to caffeine

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Authors

TCTheodore ColtonCosmos Corporation (United States)RGR.E. GosselinDartmouth College RSRoger P. SmithTwitter (United States)

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Implication

Placebo-controlled trial demonstrates bradycardia and sleep disruption after bedtime caffeine only in noncoffee drinkers, indicating acquired tolerance.

Key Points

Evaluate physiological and sleep responses to a modest bedtime dose of caffeine in habitual coffee drinkers compared to noncoffee drinkers.
Administered decaffeinated coffee powder supplemented with either 150 mg of caffeine or 150 mg of lactose placebo at bedtime to second-year medical students.
Measured changes in pulse rate and tracked self-reported sleep disturbances across habitual coffee drinkers and noncoffee drinkers.
Bedtime caffeine (150 mg) produced a statistically significant reduction in pulse rate compared to placebo in noncoffee drinkers, but elicited no significant response in habitual drinkers.
Sleep disturbances, primarily delayed sleep onset, were reported exclusively by noncoffee drinkers.
The observed bradycardia reflects heightened vagal tone, indicating that regular coffee drinkers develop an acquired, low-grade tolerance to cardiovascular and central nervous system effects.

Cite This Study

Colton et al. (1968) studied this question.

synapsesocial.com/papers/6aa8871714dd08ef654d0729 https://doi.org/10.1002/cpt19689131

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Implication

Placebo-controlled trial demonstrates bradycardia and sleep disruption after bedtime caffeine only in noncoffee drinkers, indicating acquired tolerance.

The tolerance of coffee drinkers to caffeine

Discussion

Member takes

Implication

Key Points

Cite This Study

The tolerance of coffee drinkers to caffeine

Discussion

Member takes

Implication

Key Points

Cite This Study

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