Key result
Genetically elevated LDL-C linked to increased T2DM risk in Mendelian randomization.
Why the study?
Do genetically proxied elevated LDL-C levels increase the risk of T2DM?
Observational
Do genetically proxied elevated LDL-C levels increase the risk of T2DM?
Effect estimate: Beta 0.24 (95% CI 0.087-0.393)
p-value: p=0.002
This Mendelian randomization analysis provides evidence for a causal relationship between elevated LDL-C levels and an increased risk of developing Type 2 diabetes mellitus.
Genetically elevated LDL-C linked to higher T2DM risk; hypothesis-generating and should not yet change lipid management.
) were deleted, with the remaining 23 SNPs without LD eventually being deemed as IVs. The combined effect of all these 23 SNPs on T2DM, as generated with use of the penalized robust inverse-variance weighted (IVW) method (Beta value 0.24, 95%CI 0.087~0.393, P-value=0.002) demonstrated that elevated LDL-C levels significantly increased the risk of T2DM. The relationship between LDL-C and Type 1 diabetes mellitus (T1DM) with this analysis producing negative pooled results (Beta value -0.202, 95%CI -2.888~2.484, P-value=0.883).
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Pan et al. (2020) conducted an observational in Type 2 diabetes mellitus (T2DM). Elevated LDL-C levels was evaluated on Type 2 diabetes mellitus (T2DM) (Beta 0.24, 95% CI 0.087-0.393, p=0.002). Elevated LDL-C levels significantly increased the risk of T2DM in a Mendelian randomization analysis (Beta 0.24; 95% CI 0.087-0.393; P=0.002).
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