Key result
Increased age is linked to less colorectal anastomotic leakage but ~50% higher post-leakage mortality.
Why the study?
The effect of age on colorectal anastomotic leakage (CAL) and its associated mortality after colorectal cancer surgery was unclear.
Does older age affect the incidence of colorectal anastomotic leakage and its associated mortality in patients undergoing colorectal cancer resection?
Cohort (n=45,488)
Yes
Does older age affect the incidence of colorectal anastomotic leakage and its associated mortality in patients undergoing colorectal cancer resection?
Odds Ratio: 0.965 (95% CI 0.941–0.985)
p-value: p=<0.001
While older age appears protective against colorectal anastomotic leakage, it is strongly associated with higher mortality when leakage occurs.
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Older age may signal higher post-leakage mortality risk; leaves open whether it independently protects against leakage.
Zaïmi et al. (2018) conducted a cohort in colorectal cancer (n=45,488). Increased age was evaluated on colorectal anastomotic leakage (CAL) (OR 0.965 per 5 years, 95% CI 0.941-0.985, p=<0.001). Increased age was protective against colorectal anastomotic leakage (OR 0.965 per 5 years; 95% CI 0.941-0.985; P<0.001), but was strongly associated with mortality after leakage (OR 1.497).
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