Key result
Acanthosis nigricans in obese children is linked to ~7 mg/dl higher 2-hour post-load glucose.
Why the study?
Severe obesity substantially increases diabetes risk, and hyperinsulinemia from insulin resistance and obesity associates with acanthosis nigricans, prompting evaluation of its association with glucose tolerance alterations in children.
Are glucose levels at 2 hours altered in children with obesity and acanthosis nigricans?
Cross-Sectional (n=68)
Yes
Are glucose levels at 2 hours altered in children with obesity and acanthosis nigricans?
Absolute Event Rate: 97.17% vs 90.12%
p-value: p=<0.01
Children with obesity and acanthosis nigricans have significantly altered 2-hour glucose levels, suggesting the need for routine glucose tolerance testing in this population.
May indicate need for glucose tolerance testing in obese children with acanthosis nigricans; leaves open prospective validation before changing practice.
Background: A body mass index ≥95 percentile increases 40 times the risk of diabetes. The hyperinsulinemia secondary to the resistance of insulin and obesity is associated to the development of acanthosis nigricans. The objective of current study was to associate acanthosis nigricans with childhood obesity with alterations in the curve of glucose tolerance.Methods: In current study 90 children were evaluated with obesity and acanthosis nigricans of which only 34 concluded the study. Glucose, cholesterol and triglycerides levels were determined while in fasting state, and glucose tolerance curve was conducted. The statistical analysis was done by determining X², Fisher´s test and U, Mann Whitney test.Results: Statistically significant difference was found between glucose levels at 2 hours and the presence of obesity and acanthosis nigricans (p<0.01).Conclusions: It is important that all the children with obesity and Acanthosis nigricans apply for a curve of glucose tolerance.
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Noguéz et al. (2020) conducted a cross-sectional in Childhood obesity with acanthosis nigricans (n=68). Acanthosis nigricans vs. Obese children without acanthosis nigricans was evaluated on Blood glucose level at 120 minutes during oral glucose tolerance test (p=<0.01). Obese children with acanthosis nigricans had significantly higher blood glucose levels 2 hours after an oral glucose load compared to matched obese children without the condition (97.17 vs 90.12 mg/dl, p<0.01).
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