Key result
RBC aggregation affects in vivo blood flow dynamics more than endothelial adhesion.
Why the study?
The role of red blood cell aggregation as a determinant of in vivo blood flow in health and disease has not yet been fully documented.
Comparison
RBC aggregation versus RBC adhesion to endothelial cells
Design
Brief literature review
Authors
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RBC aggregation may outweigh endothelial adhesion in microcirculatory flow; leaves open validation and therapeutic targeting in cardiovascular disease.
This review argues that red blood cell aggregation is a more critical determinant of in vivo blood flow dynamics than red blood cell adhesion to endothelial cells.
Başkurt et al. (2008) conducted a review in In vivo blood flow in health and disease. Red blood cell (RBC) aggregation vs. Red blood cell (RBC) adhesion to endothelial cells was evaluated. Literature evidence suggests that in vivo blood flow dynamics are more affected by red blood cell aggregation than by red blood cell adhesion to endothelial cells.
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