Key result
RBC adhesion to vascular endothelial cells drives circulatory disorders more potently than RBC aggregation.
Why the study?
Direct in vivo documentation comparing the impact of RBC adhesion to endothelial cells versus RBC aggregation on microcirculatory disorders was lacking.
Comparison
RBC adhesion to endothelial cells versus RBC aggregation
Design
Review
Authors
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Adherent RBCs may increase vascular resistance in vivo; hypothesis-generating for microcirculatory therapies pending clinical trials.
RBC adhesion to endothelial cells may be a more potent driver of microcirculatory disorders than RBC aggregation.
Yedgar et al. (2008) conducted a review in Circulatory disorders. RBC adhesion to vascular endothelial cells vs. RBC aggregation was evaluated on Circulatory disorders and elevation of vascular resistance. Red blood cell adhesion to vascular endothelial cells is a more potent determinant of circulatory disorders than red blood cell aggregation.
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