Key result
Bilateral uterine artery notches in preeclampsia linked to a ~341% higher perinatal death rate.
Why the study?
Are uterine artery Doppler anomalies associated with unfavorable pregnancy outcomes in patients with preeclampsia?
Cohort (n=287)
Are uterine artery Doppler anomalies associated with unfavorable pregnancy outcomes in patients with preeclampsia?
In patients with preeclampsia, abnormal uterine artery Doppler findings are associated with more severe disease and worse pregnancy outcomes, including higher perinatal mortality.
Answers are grounded in this paper and cite their sources.
May support Doppler risk stratification in preeclampsia; extends associations but leaves open need for prospective validation.
UNLABELLED: Uterine artery Doppler anomalies are associated with unfavorable outcomes in women with preeclampsia. OBJECTIVES: To examine the association between abnormal uterine artery Doppler and severity of preeclampsia. STUDY DESIGN: Retrospective analysis of a population of 287 patients with preeclampsia who underwent a uterine artery Doppler velocimetric examination at the onset of preeclampsia, between 1996 and 2002. The population was classified into three groups: Group I had normal uterine artery Doppler findings; Group II had a high uterine artery resistance index; and, Group III had both high uterine artery resistance index and bilateral notches. RESULTS: Compared to Group I, preeclampsia occurred earlier in Group II (76.3%) (p < 0.001), and HELLP syndrome was most frequent in Group III. The frequency of fetal growth restriction (pound 3(rd) percentile) was different between groups (19.1, 32.4 and 49.7% in groups I, II and III, respectively). The perinatal death rate was significantly higher in group III than the other two groups (12.8% vs 2.9%, p < 0.01). CONCLUSIONS: In patients with preeclampsia, the presence of uterine artery Doppler anomalies (high resistance index with or without bilateral notches) was associated with unfavorable pregnancy outcomes.
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Boukerrou et al. (2009) conducted a cohort in Preeclampsia (n=287). Uterine artery Doppler anomalies vs. Normal uterine artery Doppler findings was evaluated on Perinatal death rate (p=< 0.01). Uterine artery Doppler anomalies with bilateral notches in preeclampsia were associated with a higher perinatal death rate compared to normal or high resistance alone.
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