Key result
Newly diagnosed mild-to-moderate hypertension linked to decreased longitudinal myocardial function versus controls.
Why the study?
Does newly diagnosed mild-to-moderate hypertension impair longitudinal left ventricular systolic function measured by tissue Doppler echocardiography?
Cross-Sectional (n=105)
Does newly diagnosed mild-to-moderate hypertension impair longitudinal left ventricular systolic function measured by tissue Doppler echocardiography?
Newly diagnosed, untreated mild-to-moderate hypertension is associated with early impairment in longitudinal left ventricular systolic function detectable by tissue Doppler echocardiography, despite normal M-mode parameters.
Tissue Doppler strain rate may detect subclinical systolic impairment in early hypertension; leaves open whether it refines risk stratification or alters management.
OBJECTIVE: Standard echocardiographic methods reflect chamber dynamics and do not provide a direct measure of myocardial fiber shortening. Therefore we evaluated longitudinal left ventricular myocardial function by tissue Doppler echocardiography; strain (S), strain rate (SR), tissue Doppler velocity (TDV) in newly diagnosed mild to moderate hypertensive patients. METHODS: Our cross-sectional and observational study population consisted of 57 patients and 48 normotensive control subjects. Patients with obesity, diabetes mellitus, regional wall motion abnormality, secondary hypertension and a history or clinical evidence of cardiovascular disease, arrhythmias or conduction abnormalities were excluded from the study. Ejection fraction, endocardial fractional shortening (eFS), meridional end-systolic stress (mESS), stress-adjusted eFS (observed /predicted eFS) were measured by M-mode echocardiography. Relationship between the left ventricular mass index and mESS was assessed by Pearson's linear regression model. RESULTS: Hypertensive patients had significantly decreased longitudinal myocardial function compared to control subjects determined by septal (-1.25+/-0.30 vs. -1.02+/-0.33, p<0.001) and lateral (-1.20+/-0.28 vs. 1.02+/-0.41, p<0.01) SR (1/s) measurements. However, there was no significant correlation between the mESS and strain-strain rate measurements in both normal and hypertensive subjects. CONCLUSIONS: Early impairment in longitudinal left ventricular systolic function can be expected despite normal endocardial left ventricular function indicated by M-mode echocardiography in patients with newly diagnosed and never treated mild to moderate hypertension.
No takes yet. Share an insight, caveat, or question.
Atılgan et al. (2010) conducted a cross-sectional in newly diagnosed mild-to-moderate hypertension (n=105). Newly diagnosed mild-to-moderate hypertension vs. Normotensive control subjects was evaluated on Septal strain rate (1/s) (p=<0.001). Newly diagnosed mild-to-moderate hypertension was associated with significantly decreased longitudinal myocardial function compared to controls, indicated by septal strain rate (-1.25 vs -1.02; P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: