Key result
Hypertension is associated with significantly lower longitudinal systolic strain in the basal septum (16.5% vs 18.6%, p<0.01), allowing detection of segmental dysfunction before clinical symptoms.
Why the study?
Does strain rate imaging echocardiography detect early segmental systolic and diastolic left ventricular dysfunction in newly diagnosed hypertensive patients with preserved global function compared to healthy controls?
Cross-Sectional (n=64)
Single-blind
No
Does strain rate imaging echocardiography detect early segmental systolic and diastolic left ventricular dysfunction in newly diagnosed hypertensive patients with preserved global function compared to healthy controls?
Absolute Event Rate: 16.5% vs 18.6%
p-value: p=<0.01
Strain rate imaging allows for the early detection of segmental systolic and diastolic left ventricular dysfunction in hypertensive patients before the onset of clinical symptoms or global dysfunction.
Introduction: Segmental diastolic and systolic left ventricular dysfunction, caused by hypertension can by diagnosed early with strain rate imaging by echocardiography. Objective was to examine the possibilities of strain imaging echocardiography in the segmental analysis of systolic and diastolic function in patients with hypertension. Methods: 64 patients were examined, 32 newly discovered hypertensives with preserved global systolic and diastolic function, without other cardiac diseases and 32 healthy subjects of the control group. All patients underwent two-dimensional echocardiography and strain imaging methods. In both groups was a normal ejection fraction> 55% was found. To assess segmental systolic function was made systolic strain, systolic strain rate (sr) in 12 longitudinal and 12 transverse segments (basal, middle and apical levels for all four walls). Regional diastolic function was studied by determining early and late sr strain rate (E), sr (A) and sr (E) / sr (A) index. Results: Longitudinal systolic strain and strain rate were significantly lower in hypertensive patients in the basal part of the septum (p <0.01), in the basal part of the inferior wall (p <0.05) and the medial part of the septum (p <0.05). Circumferential strain and sr were significantly lower in the group of mitral septal part (p <0.01), and the strain in the mitral anterior segment (p <0.05). Lower values of sr (E) and sr (E) / sr (A) index of hypertensive patients registered in the basal septal and inferior segment (p <0.01), while in the middle septal significance for sr (E) p> 0.01 and the sr (E) / sr (A) p <0.05. Conclusion: Strain rate imaging allows detection of segmental systolic and diastolic left ventricular function before clinical symptoms.
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Lončarević et al. (2013) conducted a cross-sectional in Hypertension (n=64). Hypertension vs. Healthy subjects was evaluated on Longitudinal systolic strain in the basal part of the septum (p=<0.01). Hypertension is associated with significantly lower longitudinal systolic strain in the basal septum (16.5% vs 18.6%, p<0.01), allowing detection of segmental dysfunction before clinical symptoms.
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