Key result
Nonpulsatile spindle pump LVADs yield acceptable lung tissue damage in calves without deleterious flow effects.
Why the study?
Does the use of a nonpulsatile spindle pump as an LVAD cause deleterious histological changes in calf lung tissue?
Does the use of a nonpulsatile spindle pump as an LVAD cause deleterious histological changes in calf lung tissue?
Nonpulsatile flow from a spindle pump LVAD does not cause deleterious histological damage to lung tissue in a calf model.
The influence of the spindle pump, a nonpulsatile blood pump, used as LVAD on calf lung tissue was examined by means of the actual 16th protoype which was applied in 3 "acute" tests up to 13 hours of pumping duration and 8 prolonged experiments with pumping periods up to 63 hours. Samples were taken during the operation and after exitus of the test animal and investigated by light and electronmicroscopy. Histological findings of tissue changes could be ascribed to mechanical manipulations and shock-like influences. Regardless of the time of nonpulsatile perfusion this tissue damage remained within an acceptable range, indicating the absence of a deleterious effect of nonpulsatile flow.
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Hager et al. (1989) studied Left ventricular assisted circulation (n=11). Spindle pump (nonpulsatile blood pump) as LVAD was evaluated on Lung tissue changes assessed by light and electronmicroscopy. Nonpulsatile perfusion with the spindle pump as an LVAD in calves resulted in acceptable lung tissue damage, indicating no deleterious effect of nonpulsatile flow.
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